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  Overview Antifolates I-3D Droxidopa

Antifolates:

  • Overview
  • Indications
  • Chemistry
  • Clinical Trials
  • Publications

Antifolates: Publications

European Journal of Pharmacology 435 92002) 237 – 244
Polyglutamation of a novel antifolate, MX-68 is not necessary for its anti-arthritic effect

Cellular Pharmacology (1996) 3; 29-34
Aldehyde Oxidase Mediated 7-Hydroxylation of Antifolates and its Therapeutic Relevance

Journal Of Medicinal Chemistry, 1991
Folate Analogues, 34. Syntheseis and Antitumor Activity of Non-Polyglutamylatable Inhibitors of Dihydrofolate Reductase

Medical Chemistry Research 9:3 (1999) 176-185
Metabolism Blocked Classical Folate Analog Inhibitors of Dihydrofolate Reductase-1: Synthesis and Biological Evaluation of Mobiltrexx

Cancer Chemotherapy Pharmacology (1996) 37: 415-422
High-dose 7-hydroxymethotrexate: acute toxicity and lethality in a rat model

Cancer Chemotherapy Pharmacology (1994) 34: 119-124
Renal and hepatic toxicity after high-dose 7-hydroxymehtotrexate in the rat

Biochemical and Biophysical Research Communications, Vol. 52, No. 1, 1973
Polygammaglutamyl Metabolites of Methotrexate

Cellular Pharmacology (1994) 1, 245-245
Polyglutamylation as a determinant of cytotoxicity of classical folate analogue inhibitors of thymidylate synthase and glycinamided ribonucleotide fomyltransferase

Clinical Cancer Research, Vol. 2, 707-712, April 1996
Polyglutamylation of the Dihydrofolate Reductase Inhibitor Methylene-10-deazaaminopterin Is Not Essential for Antitumor Activity

Pharmacology and Therapeutics in the New Millennium, 2001
Metabolism-Based Antifolate Drug Design: MDAM and MTRE